EXCLUSIVE: Chinese scientists are creating CRISPR babies

A daring effort is under way to create the first children whose DNA has been tailored using gene editing.

When Chinese researchers first edited the genes of a human embryo in a lab dish in 2015, it sparked global outcry and pleas from scientists not to make a baby using the technology, at least for the present.

It was the invention of a powerful gene-editing tool, CRISPR, which is cheap and easy to deploy, that made the birth of humans genetically modified in an in vitro fertilization (IVF) center a theoretical possibility.

Now, it appears it may already be happening.

According to Chinese medical documents posted online this month (here and here), a team at the Southern University of Science and Technology, in Shenzhen, has been recruiting couples in an effort to create the first gene-edited babies. They planned to eliminate a gene called CCR5 in hopes of rendering the offspring resistant to HIV, smallpox, and cholera.

Photo of Jiankui He
He Jiankui leads a team using the gene-editing technology CRISPR in an effort to prevent disease in newborns.

Southern University of Science and Technology

The clinical trial documents describe a study in which CRISPR is employed to modify human embryos before they are transferred into women’s uteruses.

The scientist behind the effort, He Jiankui, did not reply to a list of questions about whether the undertaking had produced a live birth. Reached by telephone, he declined to comment.

However, data submitted as part of the trial listing shows that genetic tests have been carried out on fetuses as late as 24 weeks, or six months. It’s not known if those pregnancies were terminated, carried to term, or are ongoing.

[After this story was published, the Associated Press reported that according to He, one couple in the trial gave birth to twin girls this month, though the agency wasn’t able to confirm his claim independently. He also released a promotional video about his project.]

The birth of the first genetically tailored humans would be a stunning medical achievement, for both He and China. But it will prove controversial, too. Where some see a new form of medicine that eliminates genetic disease, others see a slippery slope to enhancements, designer babies, and a new form of eugenics.

“In this ever more competitive global pursuit of applications for gene editing, we hope to be a stand-out,” He and his team wrote in an ethics statement they submitted last year. They predicted their innovation “will surpass” the invention of in vitro fertilization, whose developer was awarded a Nobel Prize in 2010.

Gene-editing summit

The claim that China has already made genetically altered humans comes just as the world’s leading experts are jetting into Hong Kong for the Second International Summit on Human Genome Editing.

The purpose of the international meeting is to help determine whether humans should begin to genetically modify themselves, and if so, how. That purpose now appears to have been preempted by the actions of He, an elite biologist recruited back to China from the US as part of its “Thousand Talents Plan.”

The technology is ethically charged because changes to an embryo would be inherited by future generations and could eventually affect the entire gene pool. “We have never done anything that will change the genes of the human race, and we have never done anything that will have effects that will go on through the generations,” David Baltimore, a biologist and former president of the California Institute of Technology, who chairs the international summit proceedings, said in a pre-recorded message ahead of the event, which begins Tuesday, November 27.

It appears the organizers of the summit were also kept in the dark about He’s plans.

Regret and concern

The genetic editing of a speck-size human embryo carries significant risks, including the risks of introducing unwanted mutations or yielding a baby whose body is composed of some edited and some unedited cells. Data on the Chinese trial site indicate that one of the fetuses is a “mosaic” of cells that had been edited in different ways.

A gene-editing scientist, Fyodor Urnov, associate director of the Altius Institute for Biomedical Sciences, a nonprofit in Seattle, reviewed the Chinese documents and said that, while incomplete, they do show that “this effort aims to produce a human” with altered genes.

Urnov called the undertaking cause for “regret and concern over the fact that gene editing—a powerful and useful technique—was put to use in a setting where it was unnecessary.” Indeed, studies are already under way to edit the same gene in the bodies of adults with HIV. “It is a hard-to-explain foray into human germ-line genetic engineering that may overshadow in the mind of the public a decade of progress in gene editing of adults and children to treat existing disease,” he says.

Big project

In a scientific presentation in 2017 at Cold Spring Harbor Laboratory, which is posted to YouTube, He described a very large series of preliminary experiments on mice, monkeys, and more than 300 human embryos. One risk of CRISPR is that it can introduce accidental or “off target” mutations. But He claimed he found few or no unwanted changes in the test embryos.

He is also the chairman and founder of a DNA sequencing company called Direct Genomics. A new breed of biotech companies could ultimately reap a windfall should the new methods of conferring health benefits on children be widely employed.

Photo of stage and audience at Human Gene Editing Summit

The first International Summit on Human Gene Editing, held in December 2015 in Washington, DC. The second is taking place in Hong Kong on November 27-29, 2018.

The National Academies of Science, Engineering and Medicine

According to the clinical trial plan, genetic measurements would be carried out on embryos and would continue during pregnancy to check on the status of the fetuses. During his 2017 presentation, He acknowledged that if the first CRISPR baby were unhealthy, it could prove a disaster.

“We should do this slow and cautious, since a single case of failure could kill the whole field,” he said.

A listing describing the study was posted in November, but other trial documents are dated as early as March of 2017. That was only a month after the National Academy of Sciences in the US gave guarded support for gene-edited babies, although only if they could be created safely and under strict oversight.

Currently, using a genetically engineered embryo to establish a pregnancy would be illegal in much of Europe and prohibited in the United States. It is also prohibited in China under a 2003 ministerial guidance to IVF clinics. It is not clear if He got special permission or disregarded the guidance, which may not have the force of law.

Public opinion

In recent weeks, He has begun an active outreach campaign, speaking to ethics advisors, commissioning an opinion poll in China, and hiring an American public-relations professional, Ryan Ferrell.

“My sense is that the groundwork for future self-justification is getting laid,” says Benjamin Hurlbut, a bioethicist from Arizona State University who will attend the Hong Kong summit.

The new opinion poll, which was carried out by Sun Yat-Sen University, found wide support for gene editing among the sampled 4,700 Chinese, including a group of respondents who were HIV positive. More than 60% favored legalizing edited children if the objective was to treat or prevent disease. (Polls by the Pew Research Center have found similar levels support in the US for gene editing.)

He’s choice to edit the gene called CCR5 could prove controversial as well. People without working copies of the gene are believed to be immune or highly resistant to infection by HIV. In order to mimic the same result in embryos, however, He’s team has been using CRISPR to mutate otherwise normal embryos to damage the CCR5 gene.

The attempt to create children protected from HIV also falls into an ethical gray zone between treatment and enhancement. That is because the procedure does not appear to cure any disease or disorder in the embryo, but instead attempts to create a health advantage, much as a vaccine protects against chicken pox.

For the HIV study, doctors and AIDS groups recruited Chinese couples in which the man was HIV positive. The infection has been a growing problem in China.

So far, experts have mostly agreed that gene editing shouldn’t be used to make “designer babies” whose physical looks or personality has been changed.

He appeared to anticipate the concerns his study could provoke. “I support gene editing for the treatment and prevention of disease,” He posted in November to the social media site WeChat, “but not for enhancement or improving I.Q., which is not beneficial to society.”

Still, removing the CCR5 gene to create HIV resistance may not present a particularly strong reason to alter a baby’s heredity. There are easier, less expensive ways to prevent HIV infection. Also, editing embryos during an IVF procedure would be costly, high-tech, and likely to remain inaccessible in many poor regions of the world where HIV is rampant.

A person who knows He said his scientific ambitions appear to be in line with prevailing social attitudes in China, including the idea that the larger communal good transcends individual ethics and even international guidelines.

Behind the Chinese trial also lies some bold thinking about how evolution can be shaped by science. While the natural mutation that disables CCR5 is relatively common in parts of Northern Europe, it is not found in China. The distribution of the genetic trait around the world—in some populations but not in others—highlights how genetic engineering might be used to pick the most useful inventions discovered by evolution over the eons in different locations and bring them together in tomorrow’s children.

Such thinking could, in the future, yield people who have only the luckiest genes and never suffer Alzheimer’s, heart disease, or certain infections.

The text of an academic website that He maintains shows that he sees the technology in the same historic, and transformative, terms. “For billions of years, life progressed according to Darwin’s theory of evolution,” it states. More recently, industrialization has changed the environment in radical ways posing a “great challenge” that humanity can meet with “powerful tools to control evolution.”

It concludes: “By correcting the disease genes … we human[s] can better live in the fast-changing environment.”

Note: This story was updated after publication to include claims by He Jiankui that the trial had produced live births.

U.S Judge Ditches Islamic Female Genital Mutilation Case.

THIS IS WHY IT’S VITALLY IMPORTANT THA CHRISTIANS KNOW WHO AND WHAT THEY ARE VOTING FOR.  CHRISTIANS SHOULD NEVER CONDONE THE ADVANCEMENTS OF EVIL.  YAHWEH COMMANDED US TO STAND UP FOR THE OPPRESSED:

Psalm 9:9 ESV
The Lord is a stronghold for the oppressed, a stronghold in times of trouble.
Proverbs 14:31 ESV
Whoever oppresses a poor man insults his Maker, but he who is generous to the needy honors him.
Isaiah 1:17 ESV
Learn to do good; seek justice, correct oppression; bring justice to the fatherless, plead the widow’s cause.
Psalm 72:4 ESV
May he defend the cause of the poor of the people, give deliverance to the children of the needy, and crush the oppressor!
Psalm 34:18 ESV
The Lord is near to the brokenhearted and saves the crushed in spirit.
Zechariah 7:10 ESV
Do not oppress the widow, the fatherless, the sojourner, or the poor, and let none of you devise evil against another in your heart.”
Luke 4:18-19 ESV
“The Spirit of the Lord is upon me, because he has anointed me to proclaim good news to the poor. He has sent me to proclaim liberty to the captives and recovering of sight to the blind, to set at liberty those who are oppressed, to proclaim the year of the Lord’s favor.”
Psalm 119:134 ESV
Redeem me from man’s oppression, that I may keep your precepts.
Proverbs 22:16 ESV / 66 helpful votes
Whoever oppresses the poor to increase his own wealth, or gives to the rich, will only come to poverty.
Psalm 146:7 ESV
Who executes justice for the oppressed, who gives food to the hungry. The Lord sets the prisoners free;
Malachi 3:5 ESV
“Then I will draw near to you for judgment. I will be a swift witness against the sorcerers, against the adulterers, against those who swear falsely, against those who oppress the hired worker in his wages, the widow and the fatherless, against those who thrust aside the sojourner, and do not fear me, says the Lord of hosts.
Psalm 91:1-16 ESV
He who dwells in the shelter of the Most High will abide in the shadow of the Almighty. I will say to the Lord, “My refuge and my fortress, my God, in whom I trust.” For he will deliver you from the snare of the fowler and from the deadly pestilence. He will cover you with his pinions, and under his wings you will find refuge; his faithfulness is a shield and buckler. You will not fear the terror of the night, nor the arrow that flies by day, …
Psalm 46:1 ESV
To the choirmaster. Of the Sons of Korah. According to Alamoth. A Song. God is our refuge and strength, a very present help in trouble.
Matthew 5:1-48 ESV
Seeing the crowds, he went up on the mountain, and when he sat down, his disciples came to him. And he opened his mouth and taught them, saying: “Blessed are the poor in spirit, for theirs is the kingdom of heaven. “Blessed are those who mourn, for they shall be comforted. “Blessed are the meek, for they shall inherit the earth. …
James 2:6 ESV
But you have dishonored the poor man. Are not the rich the ones who oppress you, and the ones who drag you into court?
John 14:26 ESV
But the Helper, the Holy Spirit, whom the Father will send in my name, he will teach you all things and bring to your remembrance all that I have said to you.
Proverbs 25:26 ESV
Like a muddied spring or a polluted fountain is a righteous man who gives way before the wicked.

 Over one year ago, a Muslim doctor and his wife in Detroit Michigan were arrested for performing the barbaric Islamic practice of female genital mutilation on several young Muslim girls. On November 20 2018, Michigan’s U.S. District Judge Bernard Friedman dismissed the charges brought against them citing the law which they were arrested under is a violation of the United States Constitution.  Clearly a victory for those wanting to implement sharia law within our country.

In his 28 page opinion, Friedman states” Congress overstepped its bounds by legislating to prohibit FGM … FGM is a ‘local criminal activity’ which, in keeping with long-standing tradition and our federal system of government, is for the states to regulate, not Congress.”  Unfortunately, the defendants cannot be charged with state crimes at this time.

Female Genital Mutilation (FGM) also known as khatan, is a horrific practice performed on Muslim young girls before reaching puberty. There are four types which are:

  • Type 1 (clitoridectomy) – removing part or all of the clitoris.
  • Type 2 (excision) – removing part or all of the clitoris and the inner labia (lips that surround the vagina), with or without removal of the labia majora (larger outer lips).
  • Type 3 (infibulation) – narrowing of the vaginal opening by creating a seal, formed by cutting and repositioning the labia.
  • Other harmful procedures to the female genitals, including pricking, piercing, cutting, scraping or burning the area

The majority of these done within the United States are by Muslim doctors in clinics where no specific training is received. FGM is a painful, barbaric, and antiquated sex crime against women, which is illegal in only 27 states.

Pain killers and antiseptics aren’t generally used, and FGM is often carried out using knives, scissors, scalpels, pieces of glass or razor blades and most often happens against a girl’s will without her consent, and may be forcibly restrained. Yes in America.

But it really isn’t a surprise, since Islamic law is forcing its way into our states. As this case was ruled to be “unconstitutional”, because of a technicality, (Congress added it to the Interstate Commerce law) one must wonder was it also dismissed because it is viewed as a religious practice by Muslims? We will never know that of course, but it is in fact Islamic law that all men and women be “circumcised”.

In the classic book of Islamic law, “The Reliance of the Traveller, in section E4.3 it reads”

A question begging to be asked is where are the Muslim feminists like Linda Sarsour or Drost Kokoye? Why are they not protesting on behalf of their own young girls whose lives are being transformed everyday by this procedure?

Well, get used to this America. Islamic law..Sharia, is no longer creeping into our society, it’s gushing in. And with the November 6th election of 54 Muslims to various State, local and Federal positions, it’s going to get  worse.

Muslims now in office:

Looking up!

7 YEAR TRIBULATION GETTING CLOSER !!!  ARE YOU READY?

Jerusalem-church

(Jerusalem, Israel) — The Israeli newspaper Haaretz has just published a feature-length article exploring how American Evangelicals will react once President Trump’s Middle East peace plan is released.

I was interviewed by reporter Amir Tibon for the story, as was Dr. Darrell Bock, one of my fellow co-founders of the Alliance for the Peace of Jerusalem.

To read the article in full on-line, please click here. I found it quite fair, balanced, even nuanced.

The following are selected excerpts:

  • [A]s the Trump administration finalizes its long-expected Middle East peace plan, the bond between Trump and the evangelical community could face a serious test.
  • Trump’s Mideast team has been working on the peace plan for more than 18 months. Last week, a White House official told Haaretz that the administration is aiming to release it within the next two months. On Sunday, Israel’s Channel 10 News reported about a “crucial” meeting in the White House that will determine when and how exactly the plan will be presented….
  • The Palestinian leadership has frequently accused Trump’s son-in-law and special adviser Jared Kushner, and special envoy to the Middle East Jason Greenblatt, of being biased toward Israel. However, the administration has insisted for months that its plan will be fair toward the Palestinians, and that both sides will be required to make tough decisions once the plan becomes public.
  • If the plan does indeed include certain Israeli concessions, it could also create a dilemma for many in the U.S. evangelical community.
  • “It’s too early to say how evangelicals will respond to the plan, because we have no idea what will be the contents,” says Prof. Darrell Bock, a New Testament scholar who has also conducted research on evangelical public opinion in recent years. “However, it could definitely be uncomfortable to some evangelicals if there are territorial concessions included in it.”…..
  • “There is enormous trust among most evangelical Christians in President Trump’s love and support for Israel,” says Joel Rosenberg, an evangelical author-activist who lives in Jerusalem. Rosenberg has participated in a number of headline-making meetings over the past year between evangelical leaders and Arab heads of state, including Egyptian President Abdel-Fattah al-Sissi and, more recently, Saudi Crown Prince Mohammed bin Salman.
  • Rosenberg told Haaretz this week that if the Trump peace plan can bring Israel closer to the broader Arab world, that would make many evangelicals more eager to support it.
  • “If this leads Arab countries to get closer to Israel, most American evangelicals will give Trump enormous credit for that,” Rosenberg explains. “It would be huge inside our community. Evangelicals overwhelmingly support peace. We pray for the peace of Jerusalem.”
  • However, he concedes there are “different shades” within the evangelical world, and that “there are some evangelicals who think that if you support Israel, you should be against the Arabs and the Palestinians. But that’s not representative of all evangelicals. Most of us do care for the Palestinians and truly want to see peace and prosperity in the region,” he says….
  • Both Bock and Stearns seemingly agree with Rosenberg’s analysis about the importance of broader Arab support for the peace plan.
  • “Many evangelicals would support a plan if they saw that it enhances the stability of Israel and its acceptance by other countries in the region,” Bock says. Stearns adds that “those of us who visit Israel more frequently, and are aware of the complexity of the region and the nuances of the conflict, are very encouraged to see Israel get closer to some of its neighbors in recent years. So if there is an opportunity to make genuine peace between Israel and some of these countries in the region, we’d be in favor of that.”….https://flashtrafficblog.wordpress.com/2018/11/20/how-will-american-evangelicals-react-to-the-trump-peace-plan-here-are-the-comments-i-made-to-the-israeli-newspaper-haaretz-this-week/

Mexican Protesters March to Kick Out Caravan Migrants from Tijuana Shelters

In Tijuana, a city of migrants turns on Central American caravan that's reached the border

Mexican protesters took to the streets on Sunday to protest the growing influx of Central American migrants who have made their way to the border city of Tijuana.

In the most recent protest, groups of Tijuana residents want to evict the migrants from a shelter where approximately 2,000 Central Americans are staying. The Tijuana government set up the shelter as the city witnessed a reported buildup of federal and state police forces while the numbers of migrants continue to climb.

In two videos shared online by U.S. journalist Emily Green, dozens of protesters, some wearing wrestling masks and bandanas, can be seen marching towards the makeshift shelter.

The number of protesters appeared to grow on Sunday as the migrant caravan is starting to lose favor among certain sectors of Mexico’s northern states.

As Breitbart News reported, tensions escalated in Tijuana where some of the protests have turned violent in recent days. Law enforcement managed to keep the violence down to minor scuffles and shouting matches.

The migrants are part of a highly publicized caravan that began in mid-October. Organizers claim their ultimate goal was to reach the U.S border to claim asylum. The caravan led the U.S. government to deploy thousands of troops to border cities where they have been seen placing concertina wire along international bridges and other vulnerable areas along the border.

Ildefonso Ortiz is an award-winning journalist with Breitbart Texas.https://www.breitbart.com/border/2018/11/18/mexican-protesters-in-tijuana-march-to-kick-out-migrant-caravan/

 

LOL!!! Are U Serious!!!!

NICE!!! Chroma Key Tech charcoal briquette of “asteroid bennu”!!!! You’re getting better:) Fear mongering is getting many people into your illusion, Great Delusion is almost complete…, but don’t forget, YHWH’s always on top:)

BTW… bennu in Welsh = determine in English.  LOOK IT UP ON TRANSLATE!

Copyright Disclaimer under section 107 of the Copyright Act of 1976, allowance is made for “fair use” for purposes such as criticism, comment, news reporting, teaching, scholarship, education and research. Fair use is a use permitted by copyright statute that might otherwise be infringing.

 

The coming of the Holy Spirit did not nullify the commands of Jesus in the gospels

I had to share this article with you all:)

Enjoy.  God bless you all:))))

http://www.theelijahchallenge.org/the-coming-of-the-holy-spirit-was-not-to-nullify-the-commands-of-jesus-in-the-gospels/

Charismatic believers can place much emphasis on the work and the leading of the Holy Spirit. At times this emphasis can be taken too far by which the teaching and commands of Jesus in the gospels are superseded. But the work of the Holy Spirit is not for us to focus on him, but to testify about Jesus.

John 15:26 “When the Advocate comes, whom I will send to you from the Father—the Spirit of truth who goes out from the Father—he will testify about me.

The Greek word for “testify” is martureō, literally, “to be a witness.” The Holy Spirit is to be a witness of Jesus Christ: of who Jesus is—including of course what Jesus taught his disciples. The Holy Spirit enables us to believe in Jesus as the Son of God and the Messiah, to walk as he did and to obey his commands boldly and fruitfully.

Jesus gave various commands to his disciples in the gospels. Let’s study what he commanded them to do as they proclaimed the gospel of the kingdom to the lost.

Luke 9:1 When Jesus had called the Twelve together, he gave them power and authority to drive out all demons and to cure diseases, 2 and he sent them out to proclaim the kingdom of God and to heal the sick. …6 So they set out and went from village to village, proclaiming the good news and healing people everywhere.

Luke 10:1  After this the Lord appointed seventy-two others and sent them two by two ahead of him to every town and place where he was about to go. …9 Heal the sick who are there and tell them, ‘The kingdom of God has come near to you.’ …17 The seventy-two returned with joy and said, “Lord, even the demons submit to us in your name.”

It’s clear that when Jesus sent out the Twelve and then the Seventy-two disciples, he commanded them—not to pray to God for the sick—but rather to heal the sick and cast out demons by using the supernatural power and authority he had given them. A study of Acts following the coming of the Spirit at Pentecost reveals that the disciples continued to use this power and authority to heal the sick and cast out demons as compelling evidence of the gospel when they went out to proclaim the kingdom of God to the gentiles.

Therefore even today when disciples are proclaiming the kingdom of God to the lost, they are not simply to pray to God for the sick but rather to heal the sick using the Lord’s power and authority. But this is rarely taught in charismatic circles today due to their particular emphasis on the Holy Spirit. When ministering to the sick during evangelistic outreaches, charismatic believers today often focus on the gifts of the Spirit, in particular, “the gift of healing.” This gift, however, is separate and distinct from and not to be confused with the supernatural power and authority to heal the sick and cast out demons which Jesus gave to those he sent out to proclaim the kingdom of God. But this truth is largely neglected by the Church.

This is one reason why the miraculous healings recorded in the gospels and Acts as evidence and confirmation of the gospel are rarely seen through disciples today when they are sharing the gospel. They often rely exclusively on the gifts as led by the Spirit, and neglect the supernatural power and authority to heal the sick given them by our Lord Jesus. The use of this power and authority does not necessarily depend on “the leading of the Spirit,” but rather on our proclaiming the kingdom of God to the lost.

Supernatural power and authority are clearly to be used when proclaiming the kingdom of God—that is, in evangelism. But according to 1 Corinthians 12 the gifts, including the gift of healing, are primarily for the benefit of the body of Christ.

1 Corinthians 12: 7 Now to each one the manifestation of the Spirit is given for the common good.

From the context of this chapter, we know that “the common good” clearly refers to the good of the whole body of Christ. Therefore the gifts of the Spirit, including the gift(s) of healing, are primarily to be used in ministering to believers in the context of building up the body of Christ within the Church.

By contrast, power and authority over infirmities and demons are to be used outside the Church when proclaiming the kingdom of God to the lost. But the effective use of this power and authority are rarely taught to believers. The focus within the ministry of healing is almost always on the gift of healing. One reason for this is the unspoken assumption in many charismatic circles that after Pentecost what Jesus taught and commanded in the gospels is superseded by the leading of the Holy Spirit and his gifts. This assumption is unwarranted, and among other things robs us of the understanding of the supernatural power and authority the Lord gives to every disciple who is sent out as a witness of Jesus Christ—which includes every believer.

John 14:11  Believe me when I say that I am in the Father and the Father is in me; or at least believe on the evidence of the works themselves. 12  Very truly I tell you, whoever believes in me will do the works I have been doing, and they will do even greater things than these, because I am going to the Father.

Rather the Holy Spirit gives us power to be witnesses for the Lord Jesus (Acts 1:8), enabling us to do the miraculous works that He did as evidence to the world that He is One with the Father and the only way to Him. And such miraculous works can be done by using the supernatural power and authority already given to us.

The Holy Spirit did not come to nullify what Jesus taught, but rather to enable us to obey His commands boldly and effectively as His witnesses to the world.